Healthy Truth About Sucrose

The Healthy Truth About Sucrose Current Knowledge of the Effects of Sugar Intake

By Anne L. Mardis, MD, MPH 1 Center for Nutrition Policy and Promotion

Twenty years ago, the common perception was that sugar intake was associated with several chronic diseases: Diabetes, coronary heart disease, obesity, and hyperactivity in children. Sugar was also thought to be the sole cause of dental caries. Recent advances in scientific knowledge, however, have shed some light on the role of sugar in chronic diseases and dental caries. The evidence indicates that sugar is not in itself associated with the aforementioned chronic diseases and is not the sole offender in the development of dental caries. This research brief discusses current scientific knowledge of the health effects of sugar.

Physiology

Despite having been labeled as "empty calories," sugars are truly important compounds from the perspective of the human organism. Humans have retained the ability to synthesize all forms of carbohydrates the body needs from simple sugars. This is not the case with the other dietary macronutrients, fats, and proteins. Following ingestion, all digestible complex dietary carbohydrates are broken down in the gut to simple sugars before they are absorbed into the body. Because simple sugars are all identical chemically, the absorption process cannot distinguish simple sugars resulting from the breakdown of complex dietary carbohydrates from corresponding simple sugars occurring naturally in the foods themselves or from corresponding simple sugars added to foods during processing. Within the body, most dietary sugars are converted to glucose, a major fuel used by all cells and the primary fuel required by brain tissue for normal function. Low levels of glucose in the blood will impair the brain and cause permanent mental impairment or worse - coma or death. The body can store a limited amount of glucose as glycogen, which it can draw upon for less than a day. After this, other sources such as proteins, from the breakdown of body tissues, must be used to synthesize glucose for the cells.

Diabetes

The relationship between dietary carbohydrates and insulin resistance (a risk factor for diabetes mellitus, ischemic heart disease, and hypertension) is not clear based on available research. In two studies based on a large, prospective study of U.S. women, sucrose and carbohydrate intake were not associated with an increased risk of diabetes. However, based on the same population, associations were found between a diet with high glycemic load 2 and high intake of refined grains and the risk of diabetes. The general consensus, based on epidemiological studies, is that sugar intake alone is not associated with the development of diabetes mellitus. Sugars fed at levels equivalent to those consumed by the U.S. population do not produce adverse glycemic effects in non-diabetics. The effects of sugar intake on glucose tolerance, insulin levels, and plasma lipids are confounded by other dietary components. The American Diabetes Association has also acknowledged, in its nutrition recommendations for people with diabetes, that there is no evidence that refined sugars such as sucrose behave any differently from other types of simple carbohydrates.

Heart Disease

The Sugars Task Force of the U.S. Food and Drug Administration presented a comprehensive review of epidemiological, clinical, and animal studies dealing with the relationship between sugar intake and heart disease or risk factors for heart disease. The report concluded that at current levels of consumption, sugar is not an adverse risk factor in heart disease. The same conclusion was made by the National Research Council in its report on chronic disease risk. There is no conclusive evidence that dietary sugar is an independent risk factor for coronary artery disease in the general population.

Obesity

Despite popular belief that sugar causes obesity, a number of studies show an inverse relationship between reported sugar consumption and degree of overweight. An increase in the percentage of calories from sugar is, by definition, associated with a decreased consumption of calories from fat. Obesity is basically a consequence of higher energy intake than energy expenditure, where excess calories are stored as fat. The type of calories consumed is the subject of much study in obesity research. For instance, extra calories consumed as sugar cause an appropriate compensatory increase in carbohydrate oxidation (metabolism of carbohydrates for energy), whereas extra calories consumed as fat do not. Simply stated, obesity results from energy intake in excess of energy requirements. Many factors contribute to obesity, but evidence does not single out dietary sugar as a cause.

Hyperactivity

Many people still believe that sugar intake in children causes hyperactivity. A meta-analysis, however, of 16 different reports from 23 separate studies with 560 subjects showed virtually no effect of sugar intake on the hyperactivity in children. In a review of the literature from 12 double-blind, placebo-controlled studies, no association was found between sugar intake and hyperactive behavior. Thus, despite numerous anecdotal perceptions to the contrary, systematic, controlled studies show that sugars do not cause hyperactivity.

Dental Caries

Dental caries is a chronic disease that has many causes. Sugar is involved in tooth decay, but it is one of many factors, including oral bacteria, saliva, tooth enamel, food substrate, and host susceptibility. All fermentable carbohydrates are potentially cariogenic. Other dietary factors such as the retention of food in the mouth affect cariogenic potential. Even starches, which may not taste sweet, are chains of glucose and are broken down to glucose in the mouth. Good oral hygiene, good genes, fluoridation of water, and restricting snacks between meals can prevent tooth decay, no matter how high the sugar consumption.

Nutrient Displacement

Research on the effects of sugar intake and nutrient displacement in the diet of children is inconclusive. In a study of 143 children ages 11 and 12 years, a 7-day weighed and recorded food inventory revealed that as the proportion of energy from sugars increased, there was no decline in dietary fiber or micronutrient intake, with the exception of niacin, which exceeded recommended levels. In addition, high consumption of non-diet soft drinks, a significant source of added-sugar intake in children, is associated with lower consumption of milk and fruit juice and lower intake of riboflavin, vitamin A, calcium, phosphorus, and the ratio of calcium to phosphorus, which may be considered markers for milk consumption.

Conclusion

Recent evidence shows that aside from dental caries, the intake of added sugars is not directly related to diabetes, heart disease, obesity, and hyperactivity, as was previously thought. This conclusion was also reached in a 1997 review of the literature on the health effects of sugar intake. Because high intake of sugars along with other factors can affect oral health and can displace important foods and nutrients in the diets of children when consumed as soft drinks, it seems prudent to limit excessive intake. But the focus on sugar as an independent risk factor for chronic disease and hyperactivity should be de-emphasized.